Speech and language characteristics differentiate Alzheimer's disease and dementia with Lewy bodies.

ABSTRACT:

Introduction

Early differential diagnosis of Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) is important, but it remains challenging. Different profiles of speech and language impairments between AD and DLB have been suggested, but direct comparisons have not been investigated.

Methods

We collected speech responses from 121 older adults comprising AD, DLB, and cognitively normal (CN) groups and investigated their acoustic, prosodic, and linguistic features.

Results

The AD group showed larger differences from the CN group than the DLB group in linguistic features, while the DLB group showed larger differences in prosodic and acoustic features. Machine-learning classifiers using these speech features achieved 87.0% accuracy for AD versus CN, 93.2% for DLB

SUBMITTER: Yamada Y 

PROVIDER: S-EPMC9614050 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature