Neutrophil infiltration and myocarditis in patients with severe COVID-19: A post-mortem study.

ABSTRACT:

Aims

To investigate cardiac pathology in critically ill patients with coronavirus disease 2019 (COVID-19) and identify associations between pathological changes and clinical characteristics.

Methods

The present autopsy cohort study included hearts from 26 deceased patients hospitalized in intensive care units due to COVID-19, and was conducted at four sites in Wuhan, China. Cases were divided into a neutrophil infiltration group and a no-neutrophil group based on the presence or absence of histopathologically identified neutrophilic infiltrates.

Results

Among the 26 patients, histopathological examination identified active myocarditis in four patients. All patients with myocarditis exhibited extensive accompanying neutrophil infiltration, and all patients without myoc

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC9614157 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature