Washout DNA copy number analysis by low-coverage whole genome sequencing for assessment of thyroid FNAs.

ABSTRACT:

Background

Papillary thyroid microcarcinoma (PTMC) is defined as a papillary carcinoma measuring ≤ 10 mm. The current management of PTMC has become more conservative; however, there are high-risk tumor features that can be revealed only postoperatively. For thyroid cancer, BRAF mutations and somatic copy number variation (CNV) are the most common genetic events. Molecular testing may contribute to clinical decision-making by molecular risk stratification, for example predicting lymph node (LN) metastasis. Here, we build a risk stratification model based on molecular profiling of thyroid fine needle aspiration (FNA) washout DNA (wDNA) for the differential diagnosis of thyroid nodules.

Methods

Fifty-eight patients were recruited, FNA wDNA samples were analyzed using CNV

SUBMITTER: Wu L 

PROVIDER: S-EPMC9614279 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature