A prognostic model for cervical cancer based on ferroptosis-related genes.

ABSTRACT:

Background

Ferroptosis is widely involved in the occurrence and development of various cancers, but a specific mechanism involving ferroptosis in cervical cancer is still unclear.

Methods

Based on the expressions of ferroptosis-related genes, a prognostic model was constructed using lasso regression, and the overall predictive performance of this model was verified. An in-depth analysis of the prognostic model was then conducted.

Results

The prognostic model showed good predictive performance in both the validation and test sets. Mechanism analysis indicated that differences in the tumor microenvironment were the basis of the predictive ability of the model. Notably, CA9 mRNA was significantly overexpressed in cervical carcinoma, tissues but not in normal cervix tissu

SUBMITTER: Du H 

PROVIDER: S-EPMC9614331 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature