Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use Disorder.

ABSTRACT:

Importance

Alcohol genome-wide association studies (GWASs) have generally focused on alcohol consumption and alcohol use disorder (AUD); few have examined habitual drinking behaviors like maximum habitual alcohol intake (MaxAlc).

Objectives

To identify genetic loci associated with MaxAlc and to elucidate the genetic architecture across alcohol traits.

Design, setting, and participants

This MaxAlc genetic association study was performed among Million Veteran Program participants enrolled from January 10, 2011, to September 30, 2020. Ancestry-specific GWASs were conducted in participants with European (n = 218 623) and African (n = 29 132) ancestry, then meta-analyzed (N = 247 755). Linkage-disequilibrium score regression was used to estimate single nucleotide variant (

SUBMITTER: Deak JD 

PROVIDER: S-EPMC9614582 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature