Identification of key pharmacodynamic markers of American ginseng against heart failure based on metabolomics and zebrafish model.

ABSTRACT: Background: American ginseng (Panax quinquefolium L., AG) is a traditional Chinese medicine with multiple cardiovascular protective properties. Many bioactive components have been discovered in AG over these years. However, the understanding of these key pharmacodynamic components of activity against heart failure is insufficient. Methods: A heart failure model was established using AB line wild-type zebrafish (Danio rerio) to evaluate the anti-heart failure activity of AG. Untargeted metabolomics analysis based on ultra-high performance liquid chromatography-quadrupole electrostatic field orbitrap-mass spectrometry technology (UHPLC-QE-Orbitrap-MS) was performed to screen differential components from AG samples. The potential active components were verified usi

SUBMITTER: Dong R 

PROVIDER: S-EPMC9614665 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature