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Three-Dimensional Covalent Organic Framework with scu-c Topology for Drug Delivery.

ABSTRACT: Three-dimensional (3D) covalent organic frameworks (COFs) exemplify a new generation of crystalline extended solids with intriguing structures and unprecedented porosity. Notwithstanding substantial scope, the reticular synthesis of 3D COFs from pre-designed building units leading to new network topologies yet remains a demanding task owing to the shortage of 3D building units and inadequate reversibility of the linkages between the building units. In this work, by linking a tetragonal prism (8-connected) node with a square planar (4-connected) node, we report the first 3D COF with scu-c topology. The new COF, namely, TUS-84, features a two-fold interpenetrated structure with well-defined porosity and a Brunauer-Emmett-Teller surface area of 679 m² g^-1. In drug delivery applications, TUS-84 shows efficient drug loading and sustained release profile.

SUBMITTER: Das S

PROVIDER: S-EPMC9614725 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Three-Dimensional Covalent Organic Framework with <b>scu-c</b> Topology for Drug Delivery.

Das Saikat S Sekine Taishu T Mabuchi Haruna H Irie Tsukasa T Sakai Jin J Zhao Yu Y Fang Qianrong Q Negishi Yuichi Y

ACS applied materials & interfaces 20221017 42

Three-dimensional (3D) covalent organic frameworks (COFs) exemplify a new generation of crystalline extended solids with intriguing structures and unprecedented porosity. Notwithstanding substantial scope, the reticular synthesis of 3D COFs from pre-designed building units leading to new network topologies yet remains a demanding task owing to the shortage of 3D building units and inadequate reversibility of the linkages between the building units. In this work, by linking a tetragonal prism (8- ...[more]

PMID: 36252155

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