Biohybrid Membrane Formation by Directed Insertion of Aquaporin into a Solid-State Nanopore.

ABSTRACT: Biohybrid nanopores combine the durability of solid-state nanopores with the precise structure and function of biological nanopores. Particular care must be taken to control how biological nanopores adapt to their surroundings once they come into contact with the solid-state nanopores. Two major challenges are to precisely control this adaptability under dynamic conditions and provide predesigned functionalities that can be manipulated for engineering applications. In this work, we report on the computational design of a distinctive class of biohybrid active membrane layers, built from the directed-insertion of an aquaporin-incorporated lipid nanodisc into a model alkyl-functionalized silica pore. We show that in an aqueous environment when a pressure difference exists between the two side

SUBMITTER: Sicard F 

PROVIDER: S-EPMC9614727 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature