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Propagation of Pacemaker Activity and Peristaltic Contractions in the Mouse Renal Pelvis Rely on Ca²⁺-activated Cl^- Channels and T-Type Ca²⁺ Channels.

ABSTRACT: The process of urine removal from the kidney occurs via the renal pelvis (RP). The RP demarcates the beginning of the upper urinary tract and is endowed with smooth muscle cells. Along the RP, organized contraction of smooth muscle cells generates the force required to move urine boluses toward the ureters and bladder. This process is mediated by specialized pacemaker cells that are highly expressed in the proximal RP that generate spontaneous rhythmic electrical activity to drive smooth muscle depolarization. The mechanisms by which peristaltic contractions propagate from the proximal to distal RP are not fully understood. In this study, we utilized a transgenic mouse that expresses the genetically encoded Ca²⁺ indicator, GCaMP3, under a myosin heavy chain promotor to visualize

SUBMITTER: Grainger N

PROVIDER: S-EPMC9614935 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Dataset Information

Propagation of Pacemaker Activity and Peristaltic Contractions in the Mouse Renal Pelvis Rely on Ca²⁺-activated Cl^- Channels and T-Type Ca²⁺ Channels.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Propagation of Pacemaker Activity and Peristaltic Contractions in the Mouse Renal Pelvis Rely on Ca2+-activated Cl- Channels and T-Type Ca2+ Channels.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Propagation of Pacemaker Activity and Peristaltic Contractions in the Mouse Renal Pelvis Rely on Ca²⁺-activated Cl^- Channels and T-Type Ca²⁺ Channels.