Predictors of humoral response to SARS-CoV-2 mRNA vaccine BNT162b2 in patients receiving maintenance dialysis.

ABSTRACT:

Objective

Patients on dialysis are at high risk for severe COVID-19 and associated morbidity and mortality. We examined the humoral response to SARS-CoV-2 mRNA vaccine BNT162b2 in a maintenance dialysis population.

Design

Single-center cohort study.

Setting and participants

Adult maintenance dialysis patients at 3 outpatient dialysis units of a large academic center.

Methods

Participants were vaccinated with 2 doses of BNT162b2, 3 weeks apart. We assessed anti-SARS-CoV-2 spike antibodies (anti-S) ∼4-7 weeks after the second dose and evaluated risk factors associated with insufficient response. Definitions of antibody response are as follows: nonresponse (anti-S level, <50 AU/mL), low response (anti-S level, 50-839 AU/mL), and sufficient response (anti-S level,

SUBMITTER: Li T 

PROVIDER: S-EPMC9615013 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature