Antibiotic exposure and acquisition of antibiotic-resistant gram-negative bacteria among outpatients at a US Veterans Affairs medical center.

ABSTRACT:

Objectives

To assess the prevalence of antibiotic-resistant gram-negative bacteria (R-GNB) among patients without recent hospitalization and to examine the influence of outpatient antibiotic exposure on the risk of acquiring R-GNB in this population.

Design

2-year retrospective cohort study.

Setting

Regional Veterans Affairs healthcare system.

Patients

Outpatients at 13 community-based clinics.

Methods

We examined the rate of acquisition of R-GNB within 90 days following an outpatient visit from 2018 to 2019. We used clinical and administrative databases to determine and summarize prescriptions for systemic antibiotics, associated infectious diagnoses, and subsequent R-GNB acquisition among patients without recent hospitalizations. We also calculated the

SUBMITTER: Akpoji UC 

PROVIDER: S-EPMC9615019 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature