A novel aquaporin-4-associated optic neuritis rat model with severe pathological and functional manifestations.

ABSTRACT:

Background

Optic neuritis (ON) is a common manifestation of aquaporin-4 (AQP4) antibody seropositive neuromyelitis optica (NMO). The extent of tissue damage is frequently severe, often leading to loss of visual function, and there is no curative treatment for this condition. To develop a novel therapeutic strategy, elucidating the underlying pathological mechanism using a clinically relevant experimental ON model is necessary. However, previous ON animal models have only resulted in mild lesions with limited functional impairment. In the present study, we attempted to establish a feasible ON model with severe pathological and functional manifestations using a high-affinity anti-AQP4 antibody. Subsequently, we aimed to address whether our model is suitable for potential drug evaluat

SUBMITTER: Morita Y 

PROVIDER: S-EPMC9615200 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature