Early remission in multiple sclerosis is linked to altered coherence of the Cerebellar Network.

ABSTRACT:

Background

The development of permanent disability in multiple sclerosis (MS) is highly variable among patients, and the exact mechanisms that contribute to this disability remain unknown.

Methods

Following the idea that the brain has intrinsic network organization, we investigated changes of functional networks in MS patients to identify possible links between network reorganization and remission from clinical episodes in MS. Eighteen relapsing-remitting MS patients (RRMS) in their first clinical manifestation underwent resting-state functional MRI and again during remission. We used ten template networks, identified from independent component analysis, to compare changes in network coherence for each patient compared to those of 44 healthy controls from the Human Connectom

SUBMITTER: Tahedl M 

PROVIDER: S-EPMC9615296 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature