Precisely modeling zero-inflated count phenotype for rare variants.

ABSTRACT: Count data with excessive zeros are increasingly ubiquitous in genetic association studies, such as neuritic plaques in brain pathology for Alzheimer's disease. Here, we developed gene-based association tests to model such data by a mixture of two distributions, one for the structural zeros contributed by the Binomial distribution, and the other for the counts from the Poisson distribution. We derived the score statistics of the corresponding parameter of the rare variants in the zero-inflated Poisson regression model, and then constructed burden (ZIP-b) and kernel (ZIP-k) tests for the association tests. We evaluated omnibus tests that combined both ZIP-b and ZIP-k tests. Through simulated sequence data, we illustrated the potential power gain of our proposed method over a two-stage metho

SUBMITTER: Fan Q 

PROVIDER: S-EPMC9615426 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature