Five-year results of Amaze: a randomized controlled trial of adjunct surgery for atrial fibrillation.

ABSTRACT:

Objectives

The Amaze trial showed that adding atrial fibrillation (AF) surgery to cardiac operations increased return to sinus rhythm (SR) without impact on quality of life or survival at 2 years. We report outcomes to 5 years.

Methods

In a multicentre, phase III, pragmatic, double-blind, randomized controlled superiority trial, cardiac surgery patients with >3 months of AF were randomized 1:1 to adjunct AF surgery or control. Primary outcomes of 1-year SR restoration and 2-year quality-adjusted survival were already reported. This study reports on rhythm, survival, quality-adjusted survival, stroke, medication and safety to 5 years.

Results

Between 2009 and 2014, 352 patients were randomized. By 5 years 79 died, 58 withdrew, 34 were lost to follow-up and the remainin

SUBMITTER: Sharples LD 

PROVIDER: S-EPMC9615434 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature