An antigen processing and presentation signature for prognostic evaluation and immunotherapy selection in advanced gastric cancer.

ABSTRACT:

Objective

The aim of the study was to propose a signature based on genes associated with antigen processing and presentation (APscore) to predict prognosis and response to immune checkpoint inhibitors (ICIs) in advanced gastric cancer (aGC).

Background

How antigen presentation-related genes affected the immunotherapy response and whether they could predict the clinical outcomes of the immune checkpoint inhibitor (ICI) in aGC remain largely unknown.

Methods

In this study, an aGC cohort (Kim cohort, RNAseq, N=45) treated by ICIs, and 467 aGC patients from seven cohorts were conducted to investigate the value of the APscore predicting the prognosis and response to ICIs. Subsequently, the associations of the APscore with the tumor microenvironment (TME), molecular charact

SUBMITTER: Wang KW 

PROVIDER: S-EPMC9615473 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature