Exposure to childhood maltreatment and systemic inflammation across pregnancy: The moderating role of depressive symptomatology.

ABSTRACT:

Background

Childhood maltreatment (CM) has long-term consequences for dysregulation of the immune system which is particularly pronounced when mental and physical health sequelae have manifested. Higher proinflammatory state has been shown in non-pregnant state in association with CM as well as with depression, one of the most frequent and pernicious psychiatric sequelae of CM. During pregnancy, however, this association is less clear. Given the important role of maternal inflammatory state during pregnancy for fetal, pregnancy, and birth outcomes, we sought to examine the association between CM and proinflammatory state during pregnancy considering the moderating role of maternal depressive symptoms characterized serially across pregnancy.

Methods

A prospective, longitudina

SUBMITTER: Kleih TS 

PROVIDER: S-EPMC9615483 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature