Modafinil Does Not Reduce Cocaine Use in Methadone-Maintained Individuals.

ABSTRACT:

Introduction

There are no approved medications for the treatment of cocaine use disorder (CUD). Modafinil, a cognitive-enhancer with weak stimulant-like effects, has shown promise in initial studies as a treatment for CUD. Its potential efficacy has not been examined in individuals dually dependent on cocaine and opioids.

Methods

This study examined the efficacy of modafinil, in combination with contingency management (CM), for reducing cocaine and opioid use and improving cognitive function in methadone-stabilized individuals with opioid and cocaine dependence. We conducted a 17-week, double-blind, randomized controlled trial in which participants were randomized to one of four conditions: 1) modafinil + CM; 2) modafinil + yoked-control (YC); 3) placebo +CM; or 4) placebo +

SUBMITTER: DeVito EE 

PROVIDER: S-EPMC9615926 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature