Neuropsychiatric symptoms as a sign of small vessel disease progression in cognitive impairment.

ABSTRACT:

Background

Neuropsychiatric symptoms associate cross-sectionally with cerebral small vessel disease but it is not clear whether these symptoms could act as early clinical markers of small vessel disease progression. We investigated whether longitudinal change in Neuropsychiatric Inventory (NPI) scores associated with white matter hyperintensity (WMH) progression in a memory clinic population.

Material and methods

We included participants from the prospective Sunnybrook Dementia Study with Alzheimer's disease and vascular subtypes of mild cognitive impairment and dementia with two MRI and ≥ 1 NPI. We conducted linear mixed-effects analyses, adjusting for age, atrophy, vascular risk factors, cognition, function, and interscan interval.

Results

At baseline (n=124)

SUBMITTER: Clancy U 

PROVIDER: S-EPMC9616231 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature