Common Gray Matter Reductions in Alcohol Use and Obsessive-Compulsive Disorders: A Meta-analysis.

ABSTRACT:

Background

Though compulsive drinking is a hallmark of alcohol use disorder (AUD), little is known of the neural mechanisms driving this behavior. To further the understanding of the neural underpinnings of this compulsivity, a meta-analytic approach was used to examine gray matter (GM) volume differences related to AUD, and contrast these differences with GM volume differences in obsessive-compulsive disorder (OCD), to find common underlying regional brain differences.

Methods

We systematically meta-analyzed case-control studies investigating GM volume that used whole-brain voxel-based morphometry separately for AUD and OCD and then directly compared the results of both. Seed-based d Mapping software was used to perform the meta-analyses.

Results

The AUD meta-

SUBMITTER: Stevens BW 

PROVIDER: S-EPMC9616258 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature