Vascular burden and genetic risk in association with cognitive performance and dementia in a population-based study.

ABSTRACT:

Background and purpose

Vascular risk factors may influence cognitive function and thus represent possible targets for preventive approaches against dementia. Yet it remains unknown, if they associate with cognition independently of the individual genetic risk for dementia.

Methods

In a population-based study of 1172 community-dwelling individuals aged ≥65 years in Greece, we constructed a vascular burden score (VBS; based on presence of hypertension, diabetes, hyperlipidemia, heart disease, and cerebrovascular disease, range 0-5) and a polygenic risk score (PRS) for clinically-diagnosed Alzheimer's disease (AD) based on 23 genetic variants. We then explored in joint models the associations of the PRS for AD and VBS with global cognitive performance, cognitive performance acr

SUBMITTER: Georgakis MK 

PROVIDER: S-EPMC9616333 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature