Structural Brain Volumes of Individuals at Clinical High Risk for Psychosis: A Meta-analysis.

ABSTRACT:

Background

Structural magnetic resonance imaging studies in individuals at clinical high risk (CHR) for psychosis have yielded conflicting results.

Methods

The aims of this study were to compare intracranial and structural brain volumes and variability of CHR individuals with those of healthy control (HC) subjects and to investigate brain volume differences and variability in CHR subjects with and without transition to psychosis. The PubMed and Embase databases were searched for relevant studies published before June 1, 2020.

Results

A total of 34 studies were deemed eligible, which included baseline data of 2111 CHR and 1472 HC participants. In addition, data were included for 401 CHR subjects who subsequently transitioned to psychosis and 1023 nontransitioned CHR pa

SUBMITTER: Vissink CE 

PROVIDER: S-EPMC9616363 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature