Neuropsychiatric symptoms in patients with possible vascular cognitive impairment, does sex matter?

ABSTRACT:

Background

Neuropsychiatric symptoms (NPS) are common in patients with vascular cognitive impairment (VCI). We aimed to establish sex differences in the manifestation of NPS in memory clinic patients with possible VCI and identify which NPS are determinants of clinical progression in women and men separately.

Methods

We included 718 memory clinic patients (age 68 ± 8; 45% women) with cognitive complaints and vascular brain lesions on MRI (i.e. possible VCI). NPS were measured using the 12-item Neuropsychiatric Inventory. Clinical progression after two years (women 18%, men 14%) was defined as increase in CDR ≥1 or institutionalization (available n = 589 without advanced dementia at baseline). The association between NPS and clinical progression was assessed with Cox p

SUBMITTER: Exalto LG 

PROVIDER: S-EPMC9616441 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature