Cerebral perfusion and the risk of cognitive decline and dementia in community dwelling older people.

ABSTRACT:

Background

The arterial spin labeling-spatial coefficient of variation (sCoV) is a new vascular magnetic resonance imaging (MRI) parameter that could be a more sensitive marker for dementia-associated cerebral microvascular disease than the commonly used MRI markers cerebral blood flow (CBF) and white matter hyperintensity volume (WMHV).

Methods

195 community-dwelling older people with hypertension were invited to undergo MRI twice, with a three-year interval. Cognition was evaluated every two years for 6-8 years using the mini-mental state examination (MMSE). We assessed relations of sCoV, CBF and WMHV with cognitive decline during follow-up. We also registered dementia diagnoses, up to 9 years after the first scan. In an additional analysis, we compared these MRI parameter

SUBMITTER: Abdulrahman H 

PROVIDER: S-EPMC9616444 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature