Evolution-proof inhibitors of public good cooperation: a screening strategy inspired by social evolution theory.

ABSTRACT: Interference with public good cooperation provides a promising novel antimicrobial strategy since social evolution theory predicts that resistant mutants will be counter-selected if they share the public benefits of their resistance with sensitive cells in the population. Although this hypothesis is supported by a limited number of pioneering studies, an extensive body of more fundamental work on social evolution describes a multitude of mechanisms and conditions that can stabilize public behaviour, thus potentially allowing resistant mutants to thrive. In this paper we theorize on how these different mechanisms can influence the evolution of resistance against public good inhibitors. Based hereon, we propose an innovative 5-step screening strategy to identify novel evolution-proof public

SUBMITTER: Lissens M 

PROVIDER: S-EPMC9616471 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature