PlantPhoneDB: A manually curated pan-plant database of ligand-receptor pairs infers cell-cell communication.

ABSTRACT: Ligand-receptor pairs play important roles in cell-cell communication for multicellular organisms in response to environmental cues. Recently, the emergence of single-cell RNA-sequencing (scRNA-seq) provides unprecedented opportunities to investigate cellular communication based on ligand-receptor expression. However, so far, no reliable ligand-receptor interaction database is available for plant species. In this study, we developed PlantPhoneDB (https://jasonxu.shinyapps.io/PlantPhoneDB/), a pan-plant database comprising a large number of high-confidence ligand-receptor pairs manually curated from seven resources. Also, we developed a PlantPhoneDB R package, which not only provided optional four scoring approaches that calculate interaction scores of ligand-receptor pairs between cell typ

SUBMITTER: Xu C 

PROVIDER: S-EPMC9616517 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature