Threat history controls flexible escape behavior in mice.

ABSTRACT: In many instances, external sensory-evoked neuronal activity is used by the brain to select the most appropriate behavioral response. Predator-avoidance behaviors such as freezing and escape^1,2 are of particular interest since these stimulus-evoked responses are behavioral manifestations of a decision-making process that is fundamental to survival.^3,4 Over the lifespan of an individual, however, the threat value of agents in the environment is believed to undergo constant revision,⁵ and in some cases, repeated avoidance of certain stimuli may no longer be an optimal behavioral strategy.⁶ To begin to study this type of adaptive control of decision-making, we devised an experimental paradigm to probe the

SUBMITTER: Lenzi SC 

PROVIDER: S-EPMC9616793 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature