Piezo acts as a molecular brake on wound closure to ensure effective inflammation and maintenance of epithelial integrity.

ABSTRACT: Wound healing entails a fine balance between re-epithelialization and inflammation^1,2 so that the risk of infection is minimized, tissue architecture is restored without scarring, and the epithelium regains its ability to withstand mechanical forces. How the two events are orchestrated in vivo remains poorly understood, largely due to the experimental challenges of simultaneously addressing mechanical and molecular aspects of the damage response. Here, exploiting Drosophila's genetic tractability and live imaging potential, we uncover a dual role for Piezo-a mechanosensitive channel involved in calcium influx³-during re-epithelialization and inflammation following injury in vivo. We show that loss of Piezo leads to faster wound closure due to inc

SUBMITTER: Zechini L 

PROVIDER: S-EPMC9616804 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature