The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection.

ABSTRACT: Chronic HIV infection causes persistent low-grade inflammation that induces premature aging of the immune system including senescence of memory and effector CD8 T cells. To uncover the reasons of gradually diminished potency of CD8 T cells from people living with HIV, here we expose the T cells to planar lipid bilayers containing ligands for T-cell receptor and a T-cell integrins and analyze the cellular morphology, dynamics of synaptic interface formation and patterns of the cellular degranulation. We find a large fraction of phenotypically naive T cells from chronically infected people are capable to form mature synapse with focused degranulation, a signature of a differentiated T cells. Further, differentiation of aberrant naive T cells may lead to the development of anomalous effector

SUBMITTER: Anikeeva N 

PROVIDER: S-EPMC9616955 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature