Serotonin transporter binding in major depressive disorder: impact of serotonin system anatomy.

ABSTRACT: Serotonin transporter (5-HTT) binding deficits are reported in major depressive disorder (MDD). However, most studies have not considered serotonin system anatomy when parcellating brain regions of interest (ROIs). We now investigate 5-HTT binding in MDD in two novel ways: (1) use of a 5-HTT tract-based analysis examining binding along serotonergic axons; and (2) using the Copenhagen University Hospital Neurobiology Research Unit (NRU) 5-HT Atlas, based on brain-wide binding patterns of multiple serotonin receptor types. [¹¹C]DASB 5-HTT PET scans were obtained in 60 unmedicated participants with MDD in a current depressive episode and 31 healthy volunteers (HVs). Binding potential (BP_P) was quantified with empirical Bayesian estimation in graphical analysis (EBEGA). W

SUBMITTER: Bartlett EA 

PROVIDER: S-EPMC9616969 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature