Handgrip strength and risk of cognitive outcomes: new prospective study and meta-analysis of 16 observational cohort studies.

ABSTRACT: Handgrip strength (HGS), a measure of muscular strength, might be a risk indicator for cognitive functioning, but the evidence is not consistent. Using a new prospective study and meta-analysis of published observational cohort studies, we aimed to evaluate the prospective associations of HGS with poor cognitive outcomes including cognitive impairment, dementia and Alzheimer's disease (AD). Handgrip strength, measured using a Martin-Balloon-Vigorimeter, was assessed at baseline in a population-based sample of 852 men and women with good cognitive function in the Kuopio Ischemic Heart Disease cohort. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated for cognitive outcomes. Relevant published studies were sought in MEDLINE, Embase and Web of Science from inception until

SUBMITTER: Kunutsor SK 

PROVIDER: S-EPMC9616970 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature