Single-cell transcriptomics identifies premature aging features of TERC-deficient mouse brain and bone marrow.

ABSTRACT: Aging is a progressive loss of physiological function and increased susceptibility to major pathologies. Degenerative diseases in both brain and bone including Alzheimer disease (AD) and osteoporosis are common in aging groups. TERC is RNA component of telomerase, and its deficiency accelerates aging-related phenotypes including impaired life span, organ failure, bone loss, and brain dysfunction. In this study, we investigated the traits of bone marrow-brain cross-tissue communications in young mice, natural aging mice, and premature aging (TERC deficient, TERC-KO) mice by single-cell transcriptome sequencing. Differentially expressed gene analysis of brain as well as bone marrow between premature aging mouse and young mouse demonstrated aging-related inflammatory response and suppression

SUBMITTER: Yang C 

PROVIDER: S-EPMC9616978 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature