Cardiac troponin T and autoimmunity in skeletal muscle aging.

ABSTRACT: Age-related muscle mass and strength decline (sarcopenia) impairs the performance of daily living activities and can lead to mobility disability/limitation in older adults. Biological pathways in muscle that lead to mobility problems have not been fully elucidated. Immunoglobulin G (IgG) infiltration in muscle is a known marker of increased fiber membrane permeability and damage vulnerability, but whether this translates to impaired function is unknown. Here, we report that IgG1 and IgG4 are abundantly present in the skeletal muscle (vastus lateralis) of ~ 50% (11 out of 23) of older adults (> 65 years) examined. Skeletal muscle IgG1 was inversely correlated with physical performance (400 m walk time: r = 0.74, p = 0.005; SPPB score: r =  - 0.73, p = 0.006) and muscle strength (r =  - 0

SUBMITTER: Zhang T 

PROVIDER: S-EPMC9616986 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature