Inhibition of the 3-mercaptopyruvate sulfurtransferase-hydrogen sulfide system promotes cellular lipid accumulation.

ABSTRACT: H₂S is generated in the adipose tissue by cystathionine γ-lyase, cystathionine β-synthase, and 3-mercaptopyruvate sulfurtransferase (3-MST). H₂S plays multiple roles in the regulation of various metabolic processes, including insulin resistance. H₂S biosynthesis also occurs in adipocytes. Aging is known to be associated with a decline in H₂S. Therefore, the question arises whether endogenous H₂S deficiency may affect the process of adipocyte maturation and lipid accumulation. Among the three H₂S-generating enzymes, the role of 3-MST is the least understood in adipocytes. Here we tested the effect of the 3-MST inhibitor 2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]-1-(naphthalen-1-yl)ethan-1-one (HMPSNE) and the H₂

SUBMITTER: Casili G 

PROVIDER: S-EPMC9616987 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature