Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men.

ABSTRACT: Reduced cerebrovascular response to neuronal activation is observed in patients with neurodegenerative disease. In the present study, we examined the correlation between reduced cerebrovascular response to visual activation (ΔCBF_Vis.Act) and subclinical cognitive deficits in a human population of mid-sixties individuals without neurodegenerative disease. Such a correlation would suggest that impaired cerebrovascular function occurs before overt neurodegenerative disease. A total of 187 subjects (age 64-67 years) of the Metropolit Danish Male Birth Cohort participated in the study. ΔCBF_Vis.Act was measured using arterial spin labelling (ASL) MRI. ΔCBF_Vis.Act correlated positively with cognitive performance in: Global cognition (p = 0.046), paired associative

SUBMITTER: Vestergaard MB 

PROVIDER: S-EPMC9617000 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature