Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain.

ABSTRACT: Intermittent fasting (IF) remains the most effective intervention to achieve robust anti-aging effects and attenuation of age-related diseases in various species. Epigenetic modifications mediate the biological effects of several environmental factors on gene expression; however, no information is available on the effects of IF on the epigenome. Here, we first found that IF for 3 months caused modulation of H3K9 trimethylation (H3K9me₃) in the cerebellum, which in turn orchestrated a plethora of transcriptomic changes involved in robust metabolic switching processes commonly observed during IF. Second, a portion of both the epigenomic and transcriptomic modulations induced by IF was remarkably preserved for at least 3 months post-IF refeeding, indicating that memory of IF-induce

SUBMITTER: Ng GY 

PROVIDER: S-EPMC9617005 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature