Cancer as a biophysical disease: Targeting the mechanical-adaptability program.

ABSTRACT: With the number of cancer cases projected to significantly increase over time, researchers are currently exploring "nontraditional" research fields in the pursuit of novel therapeutics. One emerging area that is steadily gathering interest revolves around cellular mechanical machinery. When looking broadly at the physical properties of cancer, it has been debated whether a cancer could be defined as either stiffer or softer across cancer types. With numerous articles supporting both sides, the evidence instead suggests that cancer is not particularly regimented. Instead, cancer is highly adaptable, allowing it to endure the constantly changing microenvironments cancer cells encounter, such as tumor compression and the shear forces in the vascular system and body. What allows cancer cells t

SUBMITTER: Nguyen LTS 

PROVIDER: S-EPMC9617128 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature