Arene radiofluorination enabled by photoredox-mediated halide interconversion.

ABSTRACT: Positron emission tomography (PET) is a powerful imaging technology that can visualize and measure metabolic processes in vivo and/or obtain unique information about drug candidates. The identification of new and improved molecular probes plays a critical role in PET, but its progress is somewhat limited due to the lack of efficient and simple labelling methods to modify biologically active small molecules and/or drugs. Current methods to radiofluorinate unactivated arenes are still relatively limited, especially in a simple and site-selective way. Here we disclose a method for constructing C-¹⁸F bonds through direct halide/¹⁸F conversion in electron-rich halo(hetero)arenes. [¹⁸F]F^- is introduced into a broad spectrum of readily available aryl ha

SUBMITTER: Chen W 

PROVIDER: S-EPMC9617144 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature