Autonomic changes in Huntington's disease correlate with altered central autonomic network connectivity.

ABSTRACT: Autonomic dysfunction has been described in patients with Huntington's disease, but it is unclear if these changes in autonomic tone are related to the central autonomic network. We performed a pilot study to investigate the relationship between the integrity of the central autonomic network and peripheral manifestiations of autonomic dysfunction in premanifest Huntington's disease. We recruited male participants with pre-motor-manifest Huntington's disease and a comparison group consisting of healthy, male participants of approximately the same age. As this was a pilot study, only males were included to reduce confounding. Participants underwent a resting-state functional magnetic resonance imaging study to quantify functional connectivity within the central autonomic network, as well as

SUBMITTER: Schultz JL 

PROVIDER: S-EPMC9617256 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature