Dataset Information

Chinese never smokers with adenocarcinoma of the lung are younger and have fewer lymph node metastases than smokers.

ABSTRACT:

Background

Lung cancers arising in never smokers have been suggested to be substantially different from lung cancers in smokers at an epidemiological, genetic and molecular level. Focusing on non-small cell lung cancer (NSCLC), we characterized lung cancer patients in China looking for demographic and clinical differences between the smoking and never-smoking subgroups.

Methods

In total, 891 patients with NSCLC, including 841 with adenocarcinoma and 50 with squamous cell carcinoma, were recruited in this study. Association of smoking status with demographic and clinical features of NSCLC was determined, and risk factors for lymph node metastasis and TNM stage were evaluated using Multivariate logistic regression analysis.

Results

In patients with adenocarcinoma, never smokers showed a younger age at diagnosis (54.2 ± 12.7vs. 59.3 ± 9.4, p^adjusted<0.001), a lower risk for lymph node metastasis than smokers (7,6% vs. 19.5%, p^adjusted<0.001) and less severe disease as indicated by lower percentages of patients with TNM stage of III or IV (5.5% vs. 14.7%, p^adjusted<0.001 ). By contrast, these associations were not observed in 50 patients with squamous cell carcinoma. Multivariate logistic regression analysis showed that smoking status was a risk factor for lymph node metastasis (OR = 2.70, 95% CI: 1.39-5.31, p = 0.004) but not for TNM stage (OR = 1.18, 95% CI: 0.09-14.43, p = 0.896) in adenocarcinoma.

Conclusion

This study demonstrates that lung adenocarcinoma in never smokers significantly differ from those in smokers regarding both age at diagnosis and risk of lymph node metastasis, supporting the notion that they are distinct entries with different etiology and pathogenesis.

SUBMITTER: Shan L

PROVIDER: S-EPMC9617301 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Publications

Chinese never smokers with adenocarcinoma of the lung are younger and have fewer lymph node metastases than smokers.

Shan Longyu L Zhang Liang L Zhu Xiaolei X Wang Zhilin Z Fang Shaohan S Lin Junfeng J Wang Jianweng J Li Ning N Liu Hongming H Zhang Xiaowen X Feng Yihui Y Liu Jingwei J Pan Jianyun J Ye Guanzhi G Yu Xiuyi X Tufman Amanda A Katalinic Alexander A Goldmann Torsten T Petersen Frank F Jiang Jie J Geng Guojun G Yu Xinhua X

Respiratory research 20221029 1

<h4>Background</h4>Lung cancers arising in never smokers have been suggested to be substantially different from lung cancers in smokers at an epidemiological, genetic and molecular level. Focusing on non-small cell lung cancer (NSCLC), we characterized lung cancer patients in China looking for demographic and clinical differences between the smoking and never-smoking subgroups.<h4>Methods</h4>In total, 891 patients with NSCLC, including 841 with adenocarcinoma and 50 with squamous cell carcinoma ...[more]

PMID: 36309662

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Project description:BackgroundThe essential roles of the tumor microenvironment (TME) have been recognized during the initiation and progression of primary lung adenocarcinoma (LUAD). The aim of the present study was to delineate the immune landscape in both primary cancer and matched lymph node metastasis from a cohort of locally advanced stage LUAD patients with distinct outcomes.MethodsFormalin-fixed, paraffin-embedded samples were collected from 36 locally advanced LUAD patients. Transcriptome data of the tumor immune microenvironment were resolved using an immune oncology panel RNA sequencing platform. Bioinformatics approaches were used to determine the differentially expressed genes (DEGs), dysregulated pathways, and immune cell fraction between patients with early recurrence (ER) and late recurrence (LR).ResultsHere, we showed that in primary cancer tissues, 23 DEGs were obtained between patients with ER and LR. Functional analysis revealed that the LR in LUAD patients may be associated with enriched gene sets belonging to the antigen presentation and MHC protein complex, innate immune response, and IFN-γ signaling pathways. Next, the transcriptome data were adopted to quantify immune cell fractions, indicating that high infiltration of mast cells and neutrophils was correlated with ER. Interestingly, similar findings were observed in metastatic lymph nodes from patients suffering from ER or LR. By analyzing the shared immune features of primary cancers and lymphatic metastases, we unraveled the prognostic value and joint utility of two DEGs, CORO1A and S100A8.ConclusionsIn LUAD, the enrichment in antigen presentation, MHC protein complex, and IFN-γ signaling, and low infiltration of neutrophils in primary or metastatic nodules may be indications for a favorable prognosis. Integrated with bioinformatics approaches, transcriptome data of immune-related genes from formalin-fixed, paraffin-embedded (FFPE) samples can effectively profile the landscape of the tumor immune microenvironment and help predict clinical outcomes.

Dataset Information

Chinese never smokers with adenocarcinoma of the lung are younger and have fewer lymph node metastases than smokers.

Background

Methods

Results

Conclusion

Publications

Chinese never smokers with adenocarcinoma of the lung are younger and have fewer lymph node metastases than smokers.

Similar Datasets

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