Chinese never smokers with adenocarcinoma of the lung are younger and have fewer lymph node metastases than smokers.

ABSTRACT:

Background

Lung cancers arising in never smokers have been suggested to be substantially different from lung cancers in smokers at an epidemiological, genetic and molecular level. Focusing on non-small cell lung cancer (NSCLC), we characterized lung cancer patients in China looking for demographic and clinical differences between the smoking and never-smoking subgroups.

Methods

In total, 891 patients with NSCLC, including 841 with adenocarcinoma and 50 with squamous cell carcinoma, were recruited in this study. Association of smoking status with demographic and clinical features of NSCLC was determined, and risk factors for lymph node metastasis and TNM stage were evaluated using Multivariate logistic regression analysis.

Results

In patients with adenocarcinoma, never

SUBMITTER: Shan L 

PROVIDER: S-EPMC9617301 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature