Short- versus long-course antibiotic therapy for sepsis: a post hoc analysis of the nationwide cohort study.

ABSTRACT:

Background

The appropriate duration of antibiotic treatment in patients with bacterial sepsis remains unclear. The purpose of this study was to evaluate the association of a shorter course of antibiotics on 28-day mortality in comparison with a longer course using a national database in Japan.

Methods

We conducted a post hoc analysis from the retrospective observational study of patients with sepsis using a Japanese claims database from 2010 to 2017. The patient dataset was divided into short-course (≤ 7 days) and long-course (≥ 8 days) groups according to the duration of initial antibiotic administration. Subsequently, propensity score matching was performed to adjust the baseline imbalance between the two groups. The primary outcome was 28-day mortality. The secondary outc

SUBMITTER: Takahashi N 

PROVIDER: S-EPMC9617305 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature