Association between nutrient patterns and hyperuricemia: mediation analysis involving obesity indicators in the NHANES.

ABSTRACT: Diet has long been hypothesized to play an important role in hyperuricemia, and weight gain is a factor that is strongly associated with the rise in serum urate. We aimed to clarify the mediating role of obesity in the relationship between diet and hyperuricemia and to determine whether a weight-loss diet is an effective way to prevent hyperuricemia. This cross-sectional study analysed representative samples of United States (n = 20,081; NHANES 2007-2016) adults. Nutrient patterns were derived with two methods: principal component analysis (PCA) and reduced rank regression (RRR) with obesity. Logistic regression and multivariable linear regression were applied to analyse the association between nutrient patterns in obesity and hyperuricemia. Mediation analyses were used to determine whethe

SUBMITTER: Wang J 

PROVIDER: S-EPMC9617335 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature