Assessing the causal relationships between gout and hypertension: a bidirectional Mendelian randomisation study with coarsened exposures.

ABSTRACT:

Objectives

Observational studies have demonstrated associations between gout and hypertension, but whether they are causal remains unclear. Our work aims to assess the causal relationship between gout and hypertension.

Methods

We obtained genetic information from the Taiwan Biobank, including 88,347 participants and 686,439 single-nucleotide polymorphisms (SNPs). A novel model of Mendelian randomisation (MR) with coarsened exposures was used to examine the causality between the liability of gout on hypertension and vice versa, using 4 SNPs associated with gout and 10 SNPs associated with hypertension after removal of SNPs associated with measured confounders. The binary exposure (gout/hypertension) can be considered a coarsened approximation of a latent continuous trait. The

SUBMITTER: Lai B 

PROVIDER: S-EPMC9617405 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature