Mutation of the MYH3 gene causes recessive cleft palate in Limousine cattle.

ABSTRACT:

Background

The palate is a structure separating the oral and nasal cavities and its integrity is essential for feeding and breathing. The total or partial opening of the palate is called a cleft palate and is a common malformation in mammals with environmental or hereditary aetiologies. Generally, it compromises life expectancy in the absence of surgical repair. A new form of non-syndromic cleft palate arose recently in Limousine cattle, with animals referred to the French National Observatory of Bovine Abnormalities since 2012. Since the number of affected animals has increased steadily, this study was undertaken to identify the cause of this disease.

Results

Based on pedigree analysis, occurrence of cleft palate in Limousine cattle was concordant with an autosomal recessiv

SUBMITTER: Vaiman A 

PROVIDER: S-EPMC9617432 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature