FGF1^ΔHBS delays the progression of diabetic nephropathy in late-stage type 2 diabetes mouse model by alleviating renal inflammation, fibrosis, and apoptosis.

ABSTRACT: Elderly adults are at higher risk for developing diabetic complications including diabetic nephropathy (DN), contributing to excess morbidity and mortality in elderly individuals. A non-mitogenic variant of fibroblast growth factor 1 (FGF1^ΔHBS) was demonstrated to prevent DN in an early-stage (2-month-old) type 2 diabetes (T2D) mouse model. The present study aimed to investigate the potential therapeutic effects of FGF1^ΔHBS against the progression of renal dysfunction in a late-stage T2D mouse model with established DN. Nine-month-old db/db mice were administered FGF1^ΔHBS every other day for 3 months. db/db mice at 12-month-old without FGF1^ΔHBS treatment exhibited high blood glucose level and elevated urine albumin-to-creatinine ratio. FGF1^Δ

SUBMITTER: Lin Q 

PROVIDER: S-EPMC9617478 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature