Toxicology evaluation of overdose hydroxychloroquine on zebrafish (Danio rerio) embryos.

ABSTRACT: Potential risks of treatment with hydroxychloroquine (HCQ) include QT interval prolongation, hypoglycemia, a wide range of neuropsychiatric manifestations, hematotoxicity, and potential genetic defects. HCQ is extremely toxic when used in overdose and can lead to tachycardia, hypotension, known central nervous system, transmission defects, hypokalemia and other manifestations in individuals. The mechanism of excessive HCQ leading to these manifestations is still unclear. In this paper, overdose HCQ at different concentrations was used to treat zebrafish embryos, and the phenomena like human beings were obtained, such as increased heart rate and nervous system inhibition. With the increase of concentration to 100 μM, embryo mortality and malformation rate increased and hatching rate decreas

SUBMITTER: Luo M 

PROVIDER: S-EPMC9617536 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature