Chimeric antigen receptor engineered T cells and their application in the immunotherapy of solid tumours.

ABSTRACT: In this article, we reviewed the current literature studies and our understanding of the parameters that affect the chimeric antigen receptor T cells (CAR-T's) activation, effector function, in vivo persistence, and antitumour effects. These factors include T cell subsets and their differentiation stages, the components of chimeric antigen receptors (CAR) design, the expression promoters and delivery vectors, and the CAR-T production process. The CAR signalling and CAR-T activation were also studied in comparison to TCR. The last section of the review gave special consideration of CAR design for solid tumours, focusing on strategies to improve CAR-T tumour infiltration and survival in the hostile tumour microenvironment. With several hundred clinical trials undergoing worldwide, the pace o

SUBMITTER: Mao R 

PROVIDER: S-EPMC9617572 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature