Long-term antiretroviral therapy mitigates mortality and morbidity independent of HIV tropism: 18 years follow-up in a women's cohort.

ABSTRACT:

Objective

CXCR4 (X4)-tropic HIV-1 was found previously to herald CD4 + cell depletion and disease progression in individuals who were antiretroviral-naive or took combination antiretroviral therapy (cART) for less than 5 years. We updated this finding by investigating whether the deleterious effect of X4-tropic strains is mitigated by long-term cART.

Design

We examined morbidity and mortality in relation to HIV-1 tropism and cART in 529 participants followed up to 18 years in the Women's Interagency HIV Study; 91% were women of color.

Methods

Plasma-derived HIV-1 tropism was determined genotypically.

Results

We categorized participants according to the number of visits reported on cART after initiation. Group 1: three or less visits, 74% of these participants r

SUBMITTER: Weiser B 

PROVIDER: S-EPMC9617757 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature