Effect of renin-angiotensin system antihypertensive medication use on cognitive function in diabetes mellitus with obesity or overweight: An ancillary study to the Action for Health in Diabetes (Look AHEAD) trial.

ABSTRACT:

Aim

To determine whether antihypertensive medication (AHM) acting through the renin angiotensin system (RAS-AHM), compared with other AHM, can mitigate effects on cognitive function and risk for impairment in a population with type 2 diabetes mellitus (T2DM).

Materials and methods

This secondary analysis of the randomized controlled Action for Health in Diabetes (Look AHEAD) study included 712 community-dwelling participants who were followed over 15 years. Logistic regression was used to relate RAS-AHM use to cognitive impairment, and linear regression was used to relate RAS-AHM use to domain-specific cognitive function after adjusting for potential confounders.

Results

A total of 563 individuals reported RAS-AHM use and 149 reported other-AHM use during the study. R

SUBMITTER: Wharton W 

PROVIDER: S-EPMC9617758 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature