A common IL-4 receptor variant promotes asthma severity via a T_reg cell GRB2-IL-6-Notch4 circuit.

ABSTRACT:

Background

The mechanisms by which genetic and environmental factors interact to promote asthma remain unclear. Both the IL-4 receptor alpha chain R576 (IL-4RαR576) variant and Notch4 license asthmatic lung inflammation by allergens and ambient pollutant particles by subverting lung regulatory T (T_reg ) cells in an IL-6-dependent manner.

Objective

We examined the interaction between IL-4RαR576 and Notch4 in promoting asthmatic inflammation.

Methods

Peripheral blood mononuclear cells (PBMCs) of asthmatics were analyzed for T helper type 2 cytokine production and Notch4 expression on T_reg cells as a function of IL4R^R576 allele. The capacity of IL-4RαR576 to upregulate Notch4 expression on T_reg cells to promote severe allergic

SUBMITTER: Benamar M 

PROVIDER: S-EPMC9617759 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature